New Cure for 4-Hour Erections?

While studying mice lacking the gene which malfunctions

in children with severe combined immune deficiency (SCID), Yang Xia, MD, PhD, and

colleagues in the School associated with Texas, Houston, noticed the mice suffered

priapism as well as penile fibrosis.

Replacing the enzyme made through the gene -- adenosine deaminase -- not only

relieved priapism, nevertheless markedly reduced the particular animals' penile fibrosis.

"We identified a fresh application to treat priapism having a drug in which is

commonly used to treat SCID," Xia tells WebMD. Nevertheless that is actually not your worst

of it.

Men suffering penis pain along with damage from erections lasting

longer than 4 hours may take benefit of an orphan drug accustomed to tr eat severe

"bubble boy" immune deficiency, mouse studies suggest.

Your condition, referred to as priapism , seems funny only to people who have never

suffered it. more than40% of men using sickle-cell anemia suffer priapism.

It also strikes some men along with diabetes and can be a side-effect regarding erectile

dysfunction drugs -- particularly those injected in in order to the penis. the very great news is

that your treatment, PEG-ADA, is recognized to be safe throughout humans. To

do this, doctors might withdraw the blood using a needle as well as surgically install a

shunt for you to divert blood flow from the penis. "When we handled the particular mice, we do

not go to whichever unwanted effects or just about any abnormality. This usually means permanent erectile

dysfunction.

Maybe not really any kind of more. Most legal rights reserved

2009 WebMD, LLC.. While any consequence, it's an extreme ly

expensive "orphan drug" produced along with government assistance.

"This will consider a small while to obtain towards the stage of the treatment," Juneja

warns.

Xia and also colleagues report their particular findings in the Oct. Your bad

news is often that it's rarely used. 26 issue of The

FASEB Journal.

By Daniel DeNoon

Reviewed simply by Louise Chang

2005-2008 WebMD, LLC. Your result: Penile fibrosis , the actual formation of scar

tissue in the major body with the penis. We

can swiftly right the actual priapism and prevent and treat penile fibrosis."

Existing treatments

for priapism usually are usually not optimal, says Harinder Juneja, MD, the School of

Texas hematologist that treats many patients along with sickle-cell disease.

In case drug injections can't tighten the muscle in which controls blood flow in order to the

penis, the excess blood has to always be ab le to be withdrawn in the major entire body with the penis. It's not necessarily a

joke -- it can be a health-related emergency.

Swelling via priapism may be exquisitely painful. Actually, the particular mice look better. Erections lasting longer thanfour hours cut offthe provide of

fresh blood towards the penis. Aside from being painful, these

treatments usually neglect to prevent penile fibrosis.

Currently Xia along with colleagues have got found out that priapism and penile fibrosis result

from excessive levels of adenosine inside the blood.

"The discovery associated with excess adenosine because the causative factor pertaining to both

prolonged penile erection as well as penile fibrosis in mice opens up the actual possibility

of treating as well as preventing this painful as well as dangerous disorder," they

conclude.

Juneja says he's trying to obtain a clinical trial below way. Just About All rights Re served.